Piperidine → 3-[1-{3,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrol-2-yl}-meth-(z)-ylidene]-5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one

HRID 1359777Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1359777
[C:1]1([CH2:7][S:8]([C:11]2[CH:12]=[C:13]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14]3)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:21][C:22]1[C:26]([CH2:27][C:28](=[O:40])[N:29]2[CH2:33][CH2:32][CH2:31][C@H:30]2[CH2:34][N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:25]([CH3:41])[NH:24][C:23]=1[CH:42]=O.N1CCCCC1>C(O)C>[CH3:21][C:22]1[C:26]([CH2:27][C:28](=[O:40])[N:29]2[CH2:33][CH2:32][CH2:31][C@H:30]2[CH2:34][N:35]2[CH2:39][CH2:38][CH2:37][CH2:36]2)=[C:25]([CH3:41])[NH:24][C:23]=1/[CH:42]=[C:14]1\[C:15](=[O:20])[NH:16][C:17]2[C:13]\1=[CH:12][C:11]([S:8]([CH2:7][C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)(=[O:10])=[O:9])=[CH:19][CH:18]=2

Komponenten

5

Edukt 3

HCID 8082PiperidineHCID 21139221HCID 21139221, VerbindungHCID 880943273,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrole-2-carbaldehyde

Produkt 1

HCID 590774823-[1-{3,5-Dimethyl-4-[2-oxo-2-((s)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1h-pyrrol-2-yl}-meth-(z)-ylidene]-5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one (100 mg, 0.35 mmol), 3,5-dimethyl-4-[2-oxo-2-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-ethyl]-1H-pyrrole-2-carbaldehyde (110 mg, 1 eq.) and piperidine (0.5 eq.) in ethanol (2 mL) was stirred at rt for 48 hours. The reaction was concentrated, triturated with methanol, filtered and washed wit DCM to give the titled compound as a pale orange solid.

Aufarbeitung

  1. concentrationThe reaction was concentrated
  2. customtriturated with methanol
  3. filtrationfiltered
  4. washwashed wit DCM

Quellen und Nachweise

ORD-Eintrag
ord-62c45ba6a11345dfb83cc31995f68e80
Quelldatensatz
uspto-grants-2003_07
Patentnummer
US06599902B2

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