Chloroacetonitrile → 2-(4-Hydroxypiperidin-1-YL)acetonitrile
Reaktionsgleichung
[OH:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.Cl[CH2:9][C:10]#[N:11].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:9][C:10]#[N:11])[CH2:4][CH2:3]1Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 4-hydroxypyridine (4.04 g, 40 mmol), chloroacetonitrile (2.78 mL, 44 mmol) and potassium carbonate (22 g, 160 mmol) in acetonitrile (50 mL) was stirred at rt for overnight. The insolubles were filtered off, the filtrate was concentrated to give 5.6 g of (4-hydroxy-piperidin-1-yl)-acetonitrile.
Aufarbeitung
- filtrationThe insolubles were filtered off
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-9b2ecec2ff064a87b51db3bf718a57b7
- Quelldatensatz
- uspto-grants-2003_07
- Patentnummer
- US06599902B2
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