Triethylamine → HCID 59157902, Verbindung

HRID 1359936

Reaktionsgleichung

Reaktionsgleichung von HRID 1359936
[P:1]([Cl:12])(Cl)([O:3][C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][CH:5]=1)=[O:2].Cl.[CH2:14]([O:16][C:17](=[O:21])[C@H:18]([CH3:20])[NH2:19])[CH3:15].[CH3:22][CH2:23]N(CC)CC>C(Cl)Cl>[Cl:12][P:1]([NH:19][C@H:18]([C:17]([O:16][CH2:14][CH2:15][CH2:22][CH3:23])=[O:21])[CH3:20])([O:3][C:4]1[CH:5]=[CH:6][C:7]([Cl:10])=[CH:8][CH:9]=1)=[O:2]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 69879p-Chlorophenyl dichlorophosphateHCID 2724356L-Alanine, ethyl ester, hydrochloride (1:1)

Produkt 1

HCID 59157902HCID 59157902, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Following the procedure described for Example 1, step 2, treatment of a solution in DCM (0.090 M) of the commercially available 4-chlorophenyl dichlorophosphate with L-alanine ethyl ester hydrochloride (1.0 eq.) and Et3N (2.0 eq.) provided the title compound as a colorless oil as a 1.1:1* mixture of diastereoisomers. 31P NMR (400 MHz, CDCl3): δ: 9.52 and 9.28*

Quellen und Nachweise

ORD-Eintrag
ord-eaedf7c015764052a90ad976cd877017
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879815B2

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