Hydrochloric Acid → (S)-(2-amino-1-methyl-ethoxy)-acetic acid ethyl ester hydrochloric acid salt

HRID 1360167Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1360167
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][O:6][C@@H:7]([CH3:17])[CH2:8][NH:9]C(OC(C)(C)C)=O)[CH3:2].[ClH:19]>C(OCC)(=O)C>[ClH:19].[CH2:1]([O:3][C:4](=[O:18])[CH2:5][O:6][C@@H:7]([CH3:17])[CH2:8][NH2:9])[CH3:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86621906(S)-(2-t-butoxycarbonylamino-1-methyl-ethoxy)-acetic acid ethyl ester

Produkt 1

HCID 86621907(S)-(2-amino-1-methyl-ethoxy)-acetic acid ethyl ester hydrochloric acid saltAusbeute 76 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1.2 g (4.59 mmol) of (S)-(2-t-butoxycarbonylamino-1-methyl-ethoxy)-acetic acid ethyl ester was dissolved in 20 mL of ethyl acetate saturated with hydrochloric acid gas, followed by stirring at room temperature for 3 hours. The solvent was distilled off under reduced pressure, then the residue was purified by column chromatography to give 699 mg (3.49 mmol) of the title compound in a yield of 76%.

Aufarbeitung

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-ae5b067f65d1458291c982b20ef3d20e
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879848B2

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