Phosphorus oxychloride → 6-Cyanopyridine-2-carboxylic acid

HRID 1360360Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1360360
[C:1]([C:4]1[N:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[CH:6][CH:5]=1)(=O)[NH2:2].P(Cl)(Cl)(Cl)=O>>[C:1]([C:4]1[N:9]=[C:8]([C:10]([OH:12])=[O:11])[CH:7]=[CH:6][CH:5]=1)#[N:2]

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 186766986-Carbamoylpyridine-2-carboxylic acid

Produkt 1

HCID 212530396-Cyanopyridine-2-carboxylic acid

Versuchsvorschrift

6-Carbamoyl-pyridine-2-carboxylic acid (compound G1) (500 mg, 3 mmol) and phosphorus oxychloride (POCl3) (15 mL) are heated to reflux temperature for 2 h. The mixture is worked up in the usual manner and the crude product is further used without any purification.

Aufarbeitung

  1. temperatureto reflux temperature for 2 h
  2. customthe crude product is further used without any purification

Quellen und Nachweise

ORD-Eintrag
ord-f96aad530e67451382ebe34338fb2cad
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879853B2

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