Phosphorus oxychloride → 5-ethyl-1-methyl-1H-pyrazole-3-carbonitrile

Reaktionsgleichung

[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]([NH2:11])=O)[CH:4]=1)[CH3:2].P(Cl)(Cl)(Cl)=O>>[CH2:1]([C:3]1[N:7]([CH3:8])[N:6]=[C:5]([C:9]#[N:11])[CH:4]=1)[CH3:2]

Komponenten

Edukt 2

HCID 24813Phosphorus oxychloride

HCID 669585825-ethyl-1-methyl-1H-pyrazole-3-carboxamide

Produkt 1

HCID 669588435-ethyl-1-methyl-1H-pyrazole-3-carbonitrileAusbeute 79,3 %

Versuchsvorschrift

5-Ethyl-1-methyl-1H-pyrazole-3-carboxamide (3.8 g, 25 mmol) was treated with phosphorous oxychloride (18 mL, 0.19 mol) according to the method described in Part C of Example 8 to provide 2.68 g of 5-ethyl-1-methyl-1H-pyrazole-3-carbonitrile as a yellow oil.

Quellen und Nachweise

ORD-Eintrag: ord-65b76311bf4d4583ba7142d1a0339d50
Quelldatensatz: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07879849B2

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