Benzoyl chloride → 3-Benzoylamino-4-methyl-benzotrifluoride

HRID 1360836

Reaktionsgleichung

Reaktionsgleichung von HRID 1360836
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][C:16]=1[CH3:17]>N1C=CC=CC=1>[C:1]([NH:10][C:11]1[CH:12]=[C:13]([C:18]([F:19])([F:20])[F:21])[CH:14]=[CH:15][C:16]=1[CH3:17])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 7412Benzoyl chlorideHCID 27359332-Methyl-5-(trifluoromethyl)aniline

Produkt 1

HCID 579513963-Benzoylamino-4-methyl-benzotrifluorideAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

Under ice-cooling, 4.0 ml (34.5 mmol) of benzoyl chloride was added dropwise to a mixture of 4.97 g (28.8 mmol) of 3-amino-4-methyl-benzotrifluoride and 10 ml of pyridine. After stirring the mixture at room temperature for 1 hour, the solvent was removed under reduced pressure, and water was added to the residue. The precipitated solid was collected by filtration and then washed with water and a 50% aqueous methanol solution to give 8.04 g of 3-benzoylamino-4-methyl-benzotrifluoride.

Aufarbeitung

  1. temperatureUnder ice-cooling
  2. customthe solvent was removed under reduced pressure, and water
  3. additionwas added to the residue
  4. filtrationThe precipitated solid was collected by filtration
  5. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-2171ad41a7da4a56b150ef7b2cbb3795
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879887B2

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