m-Chloroperbenzoic acid → Formic Acid 4-fluoro-3,5-dimethyl-phenyl ester

Temperatur

25 °C

To a solution of 4-fluoro-3,5-dimethyl-benzaldehyde (1.0 g, 6.4 mmol) in 20 mL DCM was added mCPBA (1.2 g, 7.6 mmol) at 25° C. After being stirred for 20 h at 25° C., the reaction was quenched by the addition of 40 mL of 5% aqueous potassium carbonate. The mixture was extracted DCM (3×30 mL) and the combined DCM layer was washed with brine (2×30 mL). The solution was dried over Na2SO4 before being concentrated under reduced pressure. The crude product was used directly in the next reaction without further purification.

1. customthe reaction was quenched by the addition of 40 mL of 5% aqueous potassium carbonate
2. extractionThe mixture was extracted DCM (3×30 mL)
3. washthe combined DCM layer was washed with brine (2×30 mL)
4. dry with materialThe solution was dried over Na2SO4
5. concentrationbefore being concentrated under reduced pressure
6. customThe crude product was used directly in the next reaction without further purification

ORD-Eintrag

ord-e3a4f3bddc1644fea1604bc7bf43a7f1

Quelldatensatz

uspto-grants-2011_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07879911B2