Hydrochloric Acid → HCID 77213550, Verbindung

HRID 1361322Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1361322
[C:1]([N:8]1[CH2:12][CH2:11][C@H:10]([N:13]([CH:21]2[CH2:26][CH2:25][C:24]([CH3:28])([CH3:27])[CH2:23][CH2:22]2)[C:14](=[O:20])[C:15]([CH3:19])([CH3:18])[CH:16]=[O:17])[CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH3:29][Mg]Br.Cl>C1COCC1>[C:1]([N:8]1[CH2:12][CH2:11][CH:10]([N:13]([CH:21]2[CH2:26][CH2:25][C:24]([CH3:28])([CH3:27])[CH2:23][CH2:22]2)[C:14](=[O:20])[C:15]([CH3:19])([CH3:18])[CH:16]([OH:17])[CH3:29])[CH2:9]1)([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 86636647HCID 86636647, VerbindungHCID 178418573HCID 178418573, Verbindung

Produkt 1

HCID 77213550HCID 77213550, VerbindungAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of (3S)-1-Boc-3-[(4,4-dimethylcyclohexyl)(2,2-dimethyl-3-oxopropanoyl)amino]pyrrolidine (250 mg, 0.63 mmol) prepared in Step A of Example C3 in THF was slowly added dropwise methylmagnesium bromide (in diethylether, 3.0M, 0.25 ml, 0.76 mmol) at 0° C., and the solution was stirred at rt for 2 h. After the reaction finished, to the solution was added 1N-HCl at 0° C., and extracted with EtOAc. The organic layer was dried over MgSO4, concentrated in vacuo, and purified by column chromatography (eluent: EtOAc/Hex=1/2) to give the title compound (238 mg, 92%).

Aufarbeitung

  1. extractionextracted with EtOAc
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated in vacuo
  4. custompurified by column chromatography (eluent: EtOAc/Hex=1/2)

Quellen und Nachweise

ORD-Eintrag
ord-18f7e83d2b064d689586c2aba86695f6
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07879852B2

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