Hydrazine → 4-phenyl-1H-pyrazolo[5,4-c]pyridazin-3-amine
Reaktionsgleichung
Cl[C:2]1[N:3]=[N:4][CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:7]=1[C:8]#[N:9].[NH2:16][NH2:17]>C(O)C>[C:10]1([C:6]2[CH:5]=[N:17][N:16]=[C:2]3[NH:3][N:4]=[C:8]([NH2:9])[C:7]=23)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
3-Chloro-5-phenyl-pyridazine-4-carbonitrile obtained from Step B was suspended in 1 mL ethanol with hydrazine and the mixture was refluxed for several hours. The solvent was then evaporated and the title product was purified by silica gel chromatography (1:9 methanol/dichloromethane): MS (ES+) 212 (M+H); HPLC 1.121 minutes.
Aufarbeitung
- temperaturethe mixture was refluxed for several hours
- customThe solvent was then evaporated
- customthe title product was purified by silica gel chromatography (1:9 methanol/dichloromethane)
- customHPLC 1.121 minutes
Quellen und Nachweise
- ORD-Eintrag
- ord-c9c7c27f54a74fdca6d8e469dfcd21ad
- Quelldatensatz
- uspto-grants-2011_02
- Patentnummer
- US07883881B2
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