Hydrochloric Acid → HCID 25001867, Verbindung

HRID 1362846Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1362846
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]([NH2:13])=[O:12])[C:5]([Cl:18])=[CH:4][N:3]=1.[N:19]1([CH2:24][C:25]2[CH:26]=[C:27]([CH:29]=[CH:30][CH:31]=2)[NH2:28])[CH2:23][CH2:22][CH2:21][CH2:20]1.Cl>Cl.C(O)(C)C>[Cl:18][C:5]1[C:6]([NH:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]([NH2:13])=[O:12])=[N:7][C:2]([NH:28][C:27]2[CH:29]=[CH:30][CH:31]=[C:25]([CH2:24][N:19]3[CH2:20][CH2:21][CH2:22][CH2:23]3)[CH:26]=2)=[N:3][CH:4]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 10964073-(Pyrrolidin-1-ylmethyl)anilineHCID 579741762-[(2,5-Dichloropyrimidin-4-yl)amino]benzamide

Produkt 1

HCID 25001867HCID 25001867, VerbindungAusbeute 70,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidKatalysatorHCID 3776IsopropanolLösungsmittel

Reaktionsbedingungen

Temperatur
95 °C

Versuchsvorschrift

2-[(2,5-Dichloro-4-pyrimidinyl)amino]benzamide (200 mg, 0.6 mmol) and 3-(1-pyrrolidinylmethyl)aniline (134 mg, 0.75 mmol) were combined in a vessel with 5 mL isopropanol and 2 drops of 12N HCl. The vessel was sealed and heated with stirring at 95° C. for 18 h. The reaction was cooled to room temperature and the solid was filtered off and washed with isopropanol to give 178 mg (65% yield) of an orange solid as the HCl salt. MS: M(C22H23ClN6O)=422.92, (M+H)+=423 and 425.

Aufarbeitung

  1. customThe vessel was sealed
  2. temperatureheated
  3. temperatureThe reaction was cooled to room temperature
  4. filtrationthe solid was filtered off
  5. washwashed with isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-97bbb0e5148a4ba58785cd87304101fb
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07884098B2

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