4-Chloro-1-(chloromethyl)-2-nitrobenzene → 4-Chloro-2-nitro-DL-phenylalanine

Reaktionsgleichung

[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Cl)=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.C(C(CC)C([NH:18][CH:19](C([O-])=O)[C:20]([O-:22])=[O:21])=O)C>>[NH2:18][CH:19]([CH2:6][C:5]1[CH:8]=[CH:9][C:2]([Cl:1])=[CH:3][C:4]=1[N+:10]([O-:12])=[O:11])[C:20]([OH:22])=[O:21]

Komponenten

Edukt 2

HCID 5983994-Chloro-1-(chloromethyl)-2-nitrobenzene

HCID 21751412Diethylacetamidomalonate

Produkt 1

HCID 122325564-Chloro-2-nitro-DL-phenylalanine

Versuchsvorschrift

The title compound was prepared from 4-chloro-2-nitrobenzyl chloride and diethylacetamidomalonate according to the procedures described by Davis, A. L.; et al, in Arch. Biochem, Biophys., 102, 48 (1963).

Quellen und Nachweise

ORD-Eintrag: ord-8db41e6aa402428b8c3e8410a454cd38
Quelldatensatz: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07884113B2

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