Sodium Hydroxide → 7-(3,5-Bis(trifluoromethyl) phenoxy) heptanoic acid

HRID 1363875Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1363875
[F:1][C:2]([F:26])([F:25])[C:3]1[CH:4]=[C:5]([CH:18]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:20]=1)[O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15]CC)=[O:14].[OH-].[Na+]>C(O)C>[F:1][C:2]([F:25])([F:26])[C:3]1[CH:4]=[C:5]([CH:18]=[C:19]([C:21]([F:23])([F:24])[F:22])[CH:20]=1)[O:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 86620562Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate

Produkt 1

HCID 866205637-(3,5-Bis(trifluoromethyl) phenoxy) heptanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 7-(3,5-bis(trifluoromethyl)phenoxy)heptanoate was added to 95% ethanol and dissolved by reflux. The solution was then added with sodium hydroxide and further refluxed. The resulting crystals were filtered, washed with ethanol, and then added with dichloromethane and 1N hydrochloric acid. The solution was extracted twice with dichloromethane. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was removed and the residue was purified by silica gel column chromatography to obtain 7-(3,5-bis(trifluoromethyl) phenoxy) heptanoic acid.

Aufarbeitung

  1. dissolutiondissolved
  2. temperatureby reflux
  3. filtrationThe resulting crystals were filtered
  4. washwashed with ethanol
  5. additionadded with dichloromethane and 1N hydrochloric acid
  6. extractionThe solution was extracted twice with dichloromethane
  7. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
  8. customthe solvent was removed
  9. customthe residue was purified by silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3296fdb9656e41619f7cbfa74f7bfa1b
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07887835B2

Notizen zur Reaktion

Wird geladen…