Trifluoroacetic acid → HCID 66930841, Verbindung

HRID 1364128Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1364128
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:19]=[C:18]3[C:12]([CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][CH2:17]3)=[N:11]2)=[CH:6][CH:5]=1)=[O:3].FC(F)(F)C(O)=O>ClCCl.CO>[N:11]1[N:10]([C:7]2[CH:8]=[CH:9][C:4]([C:2]([NH2:1])=[O:3])=[CH:5][CH:6]=2)[CH:19]=[C:18]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13][C:12]=12

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 669308541,1-Dimethylethyl 2-[4-(aminocarbonyl)phenyl]-4,5,7,8-tetrahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate

Produkt 1

HCID 66930841HCID 66930841, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 1,1-dimethylethyl 2-[4-(aminocarbonyl)phenyl]-4,5,7,8-tetrahydropyrazolo[3,4-d]azepine-6(2H)-carboxylate (may be prepared as described in Description 36) (167 mg, 0.47 mmol) in dichloromethane (14 ml) was added trifluoroacetic acid (7 ml). The resulting mixture was stirred at room temperature, under argon, for 2 hours and then diluted with methanol. Reaction was purified by SCX, eluting with methanol and then 2M ammonia/methanol. The basic fractions were combined and solvent evaporated in vacuo to afford the title compound (D37). MS (ES+) m/e 257 [M+H]+.

Aufarbeitung

  1. customReaction
  2. customwas purified by SCX
  3. washeluting with methanol
  4. customsolvent evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-3f67fc08d3734df4b3d5019f6964dd3f
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07888347B2

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