HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-(4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Aminopyrimidine-5-boronic acid, pinacol ester | HCID 17750212 | — |
| Edukt | 4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine | HCID 23650837 | — |
| Produkt | 5-(4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine | HCID 46180604 | — |
Reaktionsschritte
(2-Chloro-6-((4-methylsulfonylpiperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine was reacted with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine via General Procedure B to give, after purification by reverse HPLC, 10 mg of 221. MS (Q1) 491 (M+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07888352B2 |
| Quelldatensatz | uspto-grants-2011_02 |
| ORD ID | ord-3a3888c76b7c4d0c989455be792d1b64 |
| Quellennotiz | uspto-grants-2011_02 |