Methanesulfonylmethanesulfonyl chloride → 2-Chloro-6-(4-methanesulfonylmethanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Methanesulfonylmethanesulfonyl chloride	HCID 556269	—
Edukt	4-(2-Chloro-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine	HCID 57494057	—
Lösungsmittel	Dichloromethane	HCID 6344	—
Lösungsmittel	Triethylamine	HCID 8471	—
Produkt	2-Chloro-6-(4-methanesulfonylmethanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine	HCID 87209439	—

Reaktionsschritte

To 2-chloro-4-morpholino-6-((piperazin-1-yl)methyl)thieno[3,2-d]pyrimidine (54 mg) in DCM (2 ml) and triethylamine (44 ul) was added methylsulfonylmethylsulfonyl chloride (45 ul) at 0° C. The reaction mixture was allowed to warm up to room temperature overnight. Aqueous work-up and purification on silica gave 2-chloro-6-(4-methanesulfonylmethanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (35 mg).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07888352B2
Quelldatensatz	uspto-grants-2011_02
ORD ID	ord-4f0ce4d59fae4961931ee0a6a0a1d4bf
Quellennotiz	uspto-grants-2011_02