Benzaldehyde → 2-Phenylbenzothiazole

HRID 1365592

Reaktionsgleichung

Reaktionsgleichung von HRID 1365592
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[SH:8].[CH:9](=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C1(C)C(C)=CC=CC=1>[C:10]1([C:9]2[S:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 2

HCID 240BenzaldehydeHCID 87132-Aminothiophenol

Produkt 1

HCID 134392-Phenylbenzothiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

2-Aminothiophenol (0.856 ml, 8 mmol), benzaldehyde (0.813 ml, 8 mmol), 1 g of an oxidation catalyst and 15 ml of xylene as solvent were charged into a 100 ml three-neck flask, and were stirred at 120° C. for 13 hours under an oxygen atmosphere. The reaction mixture was filtered through Celite, and then the Celite and the oxidation catalyst were washed with ethyl acetate. The filtrate was condensed with a rotary evaporator to yield a solid. The solid was recrystallized from diethyl ether. Resulting colorless crystals were then weighed and the yield thereof was defined as a reaction yield.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. washthe Celite and the oxidation catalyst were washed with ethyl acetate
  3. customcondensed
  4. customwith a rotary evaporator
  5. customto yield a solid
  6. customThe solid was recrystallized from diethyl ether
  7. customResulting colorless crystals
  8. customthe yield
  9. customyield

Quellen und Nachweise

ORD-Eintrag
ord-d61abc7cb7ff4475a705cec8cd41030f
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07893004B2

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