Methylamine → 4-((Methylamino)methyl)thiazol-2-amine
Reaktionsgleichung
Cl[CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1Komponenten
3
Versuchsvorschrift
4-(Chloromethyl)-1,3-thiazol-2-amine (490 mg, 2.65 mmol) was stirred in 40% aqueous methylamine (25 ml) overnight. The reaction mixture was evaporated. The residue was diluted with 95:5 dichloromethane/methanol (25 ml), was dried over sodium sulfate, was filtered and was evaporated to provide 4-[(methylamino)methyl]-1,3-thiazol-2-amine that was used without purification. LCMS: (M+H)+: 144.0.
Aufarbeitung
- customThe reaction mixture was evaporated
- additionThe residue was diluted with 95:5 dichloromethane/methanol (25 ml)
- dry with materialwas dried over sodium sulfate
- filtrationwas filtered
- customwas evaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-bc4cbc615a75492997445548ce2f3fe3
- Quelldatensatz
- uspto-grants-2011_02
- Patentnummer
- US07893056B2
Notizen zur Reaktion
Wird geladen…