Methylamine → 4-((Methylamino)methyl)thiazol-2-amine

Reaktionsgleichung

Cl[CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[CH3:9][NH2:10]>>[CH3:9][NH:10][CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1

Komponenten

Edukt 2

HCID 6329Methylamine

HCID 732294-Chloromethylthiazol-2-ylamine

Produkt 1

HCID 189398714-((Methylamino)methyl)thiazol-2-amineAusbeute 15 %

Versuchsvorschrift

4-(Chloromethyl)-1,3-thiazol-2-amine (490 mg, 2.65 mmol) was stirred in 40% aqueous methylamine (25 ml) overnight. The reaction mixture was evaporated. The residue was then purified via reverse phase HPLC to provide 4-[(methylamino)methyl]-1,3-thiazol-2-amine (55 mg, 15%). LCMS: (M+H)+: 144.0.

Aufarbeitung

customThe reaction mixture was evaporated
customThe residue was then purified via reverse phase HPLC

Quellen und Nachweise

ORD-Eintrag: ord-8a009e6420384e36a659e61a3afe57cc
Quelldatensatz: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07893056B2

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