Methanesulfonate → HCID 86649016, Verbindung
Reaktionsgleichung
[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][CH:9]([OH:11])[CH2:8][C@H:7]1[C:12](=[O:19])[NH:13][C:14]1([C:17]#[N:18])[CH2:16][CH2:15]1)=[O:5])[CH3:2].[S:20]([O-])(=[O:23])(=[O:22])[CH3:21]>>[CH2:1]([O:3][C:4]([C@@H:6]1[CH2:10][CH:9]([O:11][S:20]([CH3:21])(=[O:23])=[O:22])[CH2:8][C@H:7]1[C:12](=[O:19])[NH:13][C:14]1([C:17]#[N:18])[CH2:16][CH2:15]1)=[O:5])[CH3:2]Komponenten
3
Versuchsvorschrift
The mixture of (1R,2R,4R) and (1R,2R,4S)-2-(1-cyano-cyclopropylcarbamoyl)-4-hydroxy-cyclopentanecarboxylic acid ethyl ester from step 2 was converted to the corresponding mesylate according to the procedure from example 1, step 4 to give (1R,2R)-2-(1-cyano-cyclopropylcarbamoyl)-4-methanesulfonyloxy-cyclopentanecarboxylic acid ethyl ester as a 2:1 mixture of epimers as a colorless solid. MS: 345.0 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-1b056486a2d34fcdb88bfa13d51efb79
- Quelldatensatz
- uspto-grants-2011_02