2-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate → HCID 18520288, Verbindung

HRID 1368370

Reaktionsgleichung

Reaktionsgleichung von HRID 1368370
[ClH:1].C(OCC)(=O)C.[CH2:8]([NH:26][C:27](=[O:46])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([N:39]1[CH2:44][CH2:43][N:42]([CH3:45])[CH2:41][CH2:40]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]>C(OCC)(=O)C>[ClH:1].[CH2:8]([NH:26][C:27](=[O:46])[O:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH2:35][CH2:36][C:37]([N:39]1[CH2:40][CH2:41][N:42]([CH3:45])[CH2:43][CH2:44]1)=[O:38])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

Komponenten

4

Edukt 2

HCID 98074162-[3-(4-Methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamateHCID 21866389Hydrogen chloride-ethyl acetate

Produkt 1

HCID 18520288HCID 18520288, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

4N Hydrochloric acid/ethyl acetate solution (0.11 ml) was added to a solution containing 2-[3-(4-methylpiperazino)-3-oxopropyl]phenyl N-octadecylcarbamate (0.20 g) in ethyl acetate (2 ml) while being cooled with ice. After being stirred for 20 minutes, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (0.19 g) as white solid.

Aufarbeitung

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

Quellen und Nachweise

ORD-Eintrag
ord-a0a4488ec65b4f4d8870f2576ea8cbe5
Quelldatensatz
uspto-grants-2003_06
Patentnummer
US06573297B2

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