HCID 22018361, Verbindung → HCID 178435532, Verbindung

HRID 1368559Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1368559
[CH3:1][CH:2]([CH3:41])[C:3]([C:17]1[N:18]=[CH:19][N:20](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:21]=1)([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH:15]=[CH2:16])[CH:11]=2)[CH:6]=1)[OH:4]>C1COCC1.CO.[C].[Pd]>[CH2:15]([C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[CH:6]=[C:5]([C:3]([C:17]1[N:18]=[CH:19][NH:20][CH:21]=1)([OH:4])[CH:2]([CH3:41])[CH3:1])[CH:14]=[CH:13]2)[CH3:16]

Komponenten

5

Edukt 1

HCID 22018361HCID 22018361, Verbindung

Produkt 1

HCID 178435532HCID 178435532, VerbindungAusbeute 171 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

2-Methyl-1-(1-trityl-1H-imidazol-4-yl)-1-(6-vinylnaphthalen-2-yl)-1-propanol (1.20 g) was dissolved in THF (5 ml)-methanol (10 ml). To the solution was added 10% palladium carbon (120 mg), and the mixture was stirred at room temperature for 2 h under hydrogen atmosphere. The catalyst was filtered off and washed with THF. The filtrate was concentrated and the residue was recrystallized from isopropyl ether-hexane (1:1) to give the titled compound (1.13 g) as a colorless powder.

Aufarbeitung

  1. filtrationThe catalyst was filtered off
  2. washwashed with THF
  3. concentrationThe filtrate was concentrated
  4. customthe residue was recrystallized from isopropyl ether-hexane (1:1)

Quellen und Nachweise

ORD-Eintrag
ord-d69291a1ef6941c290837949f3ed369c
Quelldatensatz
uspto-grants-2003_06
Patentnummer
US06573289B1

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