Ddctp → 2',3'-Dideoxyuridine-5'-triphosphate

HRID 1368572

Reaktionsgleichung

[P:1]([O:13][CH2:14][C@H:15]1[O:19][C@@H:18]([N:20]2[CH:27]=[CH:26][C:24](N)=[N:23][C:21]2=[O:22])[CH2:17][CH2:16]1)([O:4][P:5]([O:8][P:9]([OH:12])([OH:11])=[O:10])([OH:7])=[O:6])(=[O:3])[OH:2].N([O-])=[O:29].[Na+].C(O)(=O)C>>[P:1]([O:13][CH2:14][C@H:15]1[O:19][C@@H:18]([N:20]2[CH:27]=[CH:26][C:24](=[O:29])[NH:23][C:21]2=[O:22])[CH2:17][CH2:16]1)([O:4][P:5]([O:8][P:9]([OH:11])([OH:12])=[O:10])([OH:7])=[O:6])(=[O:3])[OH:2]

Komponenten

Edukt 2

HCID 119119Ddctp

HCID 86611488NaNO2 acetic acid

Produkt 1

HCID 722452',3'-Dideoxyuridine-5'-triphosphate

Versuchsvorschrift

The derivative was synthesized via the unstable diazonium derivative starting with the commercially available 2′,3′-dideoxy-cytidine-5′-triphosphate (Boehringer Mannheim) by deamination with NaNO2/acetic acid.

Quellen und Nachweise

ORD-Eintrag: ord-810df20c1e8148f297e8f84737b4c819
Quelldatensatz: uspto-grants-2003_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06573374B1

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