Acetic acid, azido-, ethyl ester → HCID 59648496, Verbindung
Reaktionsgleichung
[F:1][C:2]1[S:6][C:5]([CH:7]=O)=[CH:4][CH:3]=1.[CH2:9]([O:11][C:12](=[O:17])[CH2:13][N:14]=[N+]=[N-])[CH3:10]>C(O)C>[CH2:9]([O:11][C:12]([C:13]1[NH:14][C:4]2[CH:3]=[C:2]([F:1])[S:6][C:5]=2[CH:7]=1)=[O:17])[CH3:10]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
5-Fluoro-thiophene-2-carbaldehyde (see, for example, Schuetz, R. D. and Nilles, G. P., J. Org. Chem., 36: 2188-90 (1971)) was annulated according to Procedure H (aldehyde and azido-acetic acid ethyl ester added as ethanol solution (0.6 M of ester); acrylate organic phase washed with saturated aqueous NaCl prior to drying; acrylate not purified).
Aufarbeitung
- washacrylate organic phase washed with saturated aqueous NaCl
- customto drying
- customacrylate not purified)
Quellen und Nachweise
- ORD-Eintrag
- ord-d13f738fdade488f9f6de23d5b82b5c2
- Quelldatensatz
- uspto-grants-2003_06
- Patentnummer
- US06576653B2
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