HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 137Erstellt: 23. Oktober 2026
3-Aminoazetidine, 3-BOC protected → tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate
https://huagongshe.com/de/reaction/137
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 3-Aminoazetidine, 3-BOC protected | HCID 1519405 | — |
| Edukt | 4-Bromo-2-methoxypyridine | HCID 14062309 | — |
| Reagenz | Sodium t-butoxide | HCID 23676156 | — |
| Katalysator | Binap, (A+-)- | HCID 634876 | — |
| Katalysator | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | tert-butyl N-[1-(2-methoxy-4-pyridinyl)azetidin-3-yl]carbamate | HCID 118055029 | 99,96% |
Reaktionsschritte
A mixture of all the reactants in toluene was heated in a sealed vial at 70 °C overnight. According to LC-MS the reaction was completed and the product had been formed. Toluene was removed, water was added and the product was extracted with DCM. The organic phase was dried through phase separator and concentrated.
Herkunft & Nachweise
| Quelldatensatz | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-f3ebf4dfde174cff92751e3b49ce74da |
|---|
| Quellennotiz | 750 AstraZeneca ELN dataset |
|---|
