Sodium Hydroxide → 2-Amino-4-phenylpyrimidine-5-carbonitrile
Reaktionsgleichung
C(=O)(O)O.[NH2:5][C:6]([NH2:8])=[NH:7].[C:9]1([C:15](=O)[C:16]([C:21]#N)=[CH:17][N:18](C)C)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[OH-].[Na+]>>[NH2:7][C:6]1[N:8]=[C:15]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:16]([C:17]#[N:18])=[CH:21][N:5]=1Komponenten
4
Versuchsvorschrift
2-Amino-5-cyano-4-phenylpyrimidine was prepared from guanidine carbonate (1.57 g, 17.5 mmol), 1-phenyl-2-cyano-3-dimethylaminopropen-1-one (3.5 g, 17.5 mmol) and sodium hydroxide (720 mg, 19.3 mmol) in a similar method to the compound of Example 1, as an off-white solid, m.p. 147°.
Quellen und Nachweise
- ORD-Eintrag
- ord-16b657bd1a3b431baadcd57bb19135fc
- Quelldatensatz
- uspto-grants-2003_06
- Patentnummer
- US06579983B1
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