Ethyl N-methylaminoacetate hydrochloride → HCID 18512199, Verbindung
Reaktionsgleichung
[F:1][C:2]1[CH:42]=[C:41]([F:43])[CH:40]=[CH:39][C:3]=1[CH2:4][N:5]([CH2:18][C:19]1[CH:38]=[CH:37][C:22]([O:23][C:24]2[CH:25]=[C:26]([CH:34]=[CH:35][CH:36]=2)[O:27][CH2:28][CH2:29][CH2:30][C:31](O)=[O:32])=[CH:21][CH:20]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[C:7]=1[CH3:17].Cl.C([O:47][C:48](=[O:52])[CH2:49][NH:50][CH3:51])C>>[F:1][C:2]1[CH:42]=[C:41]([F:43])[CH:40]=[CH:39][C:3]=1[CH2:4][N:5]([CH2:18][C:19]1[CH:38]=[CH:37][C:22]([O:23][C:24]2[CH:25]=[C:26]([CH:34]=[CH:35][CH:36]=2)[O:27][CH2:28][CH2:29][CH2:30][C:31]([N:50]([CH3:51])[CH2:49][C:48]([OH:47])=[O:52])=[O:32])=[CH:21][CH:20]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([NH:12][S:13]([CH3:16])(=[O:15])=[O:14])[C:7]=1[CH3:17]Komponenten
3
Versuchsvorschrift
The product from Example 120D and sarcosine ethyl ester hydrochloride was processed as described in Example 104B to provide the title compound. 1H NMR (300 MHz, DMSO-d6) δ8.96 (s, 1 H), 6.85-7.34 (m, 11 H), 6.69 (m, 1 H), 6.49 (m, 2 H), 4.08 (s, 2 H), 4.05 (s, 2 H), 3.94 (m, 4 H), 2.98 (s, 3 H), 2.89 (s, 3 H), 2.80 (s, 1 H), 2.50 (m, 2 H), 2.33 (s, 3 H), 1.90 (m, 2 H); MS (ESI) m/z 682 (M+H+).
Quellen und Nachweise
- ORD-Eintrag
- ord-1ead1dcfda554b32b8e0fc1434bd7d41
- Quelldatensatz
- uspto-grants-2003_06