(S)-(4-(3,4-Dichlorobenzyl)morpholin-2-YL)methanamine → 4-Nitrophenyl [(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methylcarbamate
Reaktionsgleichung
[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:14](=[O:25])[O:15][C:16]2[CH:21]=[CH:20][C:19]([N+:22]([O-:24])=[O:23])=[CH:18][CH:17]=2)[CH2:7]1.ClC1C=C(C=CC=1Cl)CN1CCO[C@@H](CN)C1.C1C([N+]([O-])=O)=CC=C([Cl-]C([O-])=O)C=1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][C@@H:8]([CH2:12][NH:13][C:14](=[O:25])[O:15][C:16]2[CH:17]=[CH:18][C:19]([N+:22]([O-:24])=[O:23])=[CH:20][CH:21]=2)[CH2:7]1Komponenten
3
Versuchsvorschrift
Intermediate 13 was prepared in an analogous manner to Intermediate 10 from Intermediate 11 (0.225 g) and 4-nitrophenylchloroformate (0.182 g) to yield the title compound (0.2 g).
Quellen und Nachweise
- ORD-Eintrag
- ord-63e2476fb7eb4231899ca888c34c1c26
- Quelldatensatz
- uspto-grants-2007_01