Hydrochloric Acid → HCID 17984664, Verbindung

HRID 1371387Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1371387
[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[Cl:33])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:14]([NH:16][CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[O:15])[CH2:7]1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[Cl:33])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:14]([NH:16][CH:17]2[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]2)=[O:15])[CH2:7]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 17984711tert-Butyl 4-{[({[4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]amino}piperidine-1-carboxylate

Produkt 1

HCID 17984664HCID 17984664, VerbindungAusbeute 175,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

Intermediate 15 (0.157 g) was stirred in dioxane (4 ml) containing 4.0M hydrogen chloride in dioxane (0.78 ml) for 16 h, at 23° C. under nitrogen. The solvent was removed in vacuo, azeotroped with dichloromethane (20 ml), triturated in ether and dried under vacuum to give the title compound as a pale yellow solid (0.12 g).

Aufarbeitung

  1. customat 23° C.
  2. customThe solvent was removed in vacuo
  3. customazeotroped with dichloromethane (20 ml)
  4. customtriturated in ether
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-ccb0673f839c41068d88f92c37a6d083
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157457B2

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