2-Aminopropanol → 2-{[(3,4-Dichlorophenyl)methyl]amino}propan-1-ol

HRID 1371401

Reaktionsgleichung

Reaktionsgleichung von HRID 1371401
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5]Cl.[NH2:11][CH:12]([CH3:15])[CH2:13][OH:14]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH:11][CH:12]([CH3:15])[CH2:13][OH:14]

Komponenten

3

Edukt 2

HCID 51262-AminopropanolHCID 76093,4-Dichlorobenzyl chloride

Produkt 1

HCID 219629772-{[(3,4-Dichlorophenyl)methyl]amino}propan-1-olAusbeute 79 %

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

3,4-Dichlorobenzyl chloride (0.988 g) was added to 2-amino-1-propanol (4.10 g) and the mixture was stirred at 50° C. under nitrogen for 2 h. The mixture was partitioned between saturated aqueous sodium bicarbonate (100 ml) and ethyl acetate (100 ml) and the phases were separated. The organic layer was washed with water (4×100 ml) and brine, dried (Na2SO4) then concentrated under vacuum to give the title compound as a white solid (0.935 g).

Aufarbeitung

  1. customThe mixture was partitioned between saturated aqueous sodium bicarbonate (100 ml) and ethyl acetate (100 ml)
  2. customthe phases were separated
  3. washThe organic layer was washed with water (4×100 ml) and brine
  4. dry with materialdried (Na2SO4)
  5. concentrationthen concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-fc91a1e74e0f49db8cc2e334f08fcc05
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157457B2

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