p-Vinylbenzyl chloride → N-(4-Chlorophenyl)-N'-{[4-(4-vinylbenzyl)morpholin-2-yl]methyl}urea
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][NH:15][CH2:14]2)=[O:10])=[CH:4][CH:3]=1.Cl[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([CH:27]=[CH2:28])=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([NH:11][CH2:12][CH:13]2[O:18][CH2:17][CH2:16][N:15]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([CH:27]=[CH2:28])=[CH:23][CH:22]=3)[CH2:14]2)=[O:10])=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
Example 38 was prepared in an analogous manner to Example 19 using a mixture of Intermediate 9 (0.01 g) and 1-(chloromethyl)-4-vinylbenzene (0.0062 g) to give the title compound (0.0071 g). LC-MS (System A): Rt 2.72 mins, Mass Spectrum m/z 386 [MH+].
Aufarbeitung
- customExample 38 was prepared in an analogous manner to Example 19 using