3-Acetamidobenzylamine → HCID 69507141, Verbindung

HRID 1371443Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1371443
[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:14](=[O:25])[O:15]C2C=CC([N+]([O-])=O)=CC=2)[CH2:7]1.[C:30]([NH:33][C:34]1[CH:35]=[C:36]([CH:39]=[CH:40][CH:41]=1)[CH2:37][NH2:38])(=[O:32])[CH3:31]>>[CH:14]([OH:25])=[O:15].[Cl:1][C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:5][N:6]1[CH2:11][CH2:10][O:9][CH:8]([CH2:12][NH:13][C:14]([NH:38][CH2:37][C:36]2[CH:35]=[C:34]([NH:33][C:30](=[O:32])[CH3:31])[CH:41]=[CH:40][CH:39]=2)=[O:25])[CH2:7]1

Komponenten

3

Edukt 2

HCID 27609463-AcetamidobenzylamineHCID 115394484-Nitrophenyl [4-(3,4-dichlorobenzyl)morpholin-2-yl]methylcarbamate

Produkt 1

HCID 69507141HCID 69507141, VerbindungAusbeute 34,4 %

Versuchsvorschrift

Example 52 was prepared in an analogous manner to Example 43 from Intermediate 10 (0.04 g) and 3-acetamidobenzylamine (0.022 g), and purified by Mass Directed Automated Preparative HPLC to yield the title compound (0.008 g).

Aufarbeitung

  1. custompurified by Mass Directed Automated Preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-e0f66619635946cd82c4e3e4b10e6afa
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157457B2

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