1,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride → HCID 58777591, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[N:3]=1.[CH3:26][N:27]1[C:31]([CH3:32])=[C:30]([S:33](Cl)(=[O:35])=[O:34])[C:29]([CH3:37])=[N:28]1>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:21][CH2:22][N:23]([S:33]([C:30]3[C:29]([CH3:37])=[N:28][N:27]([CH3:26])[C:31]=3[CH3:32])(=[O:34])=[O:35])[CH2:24][CH2:25]2)[N:3]=1Komponenten
3
Versuchsvorschrift
The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone, Example 59, and 1,3,5-trimethyl-1H-pyrazole-4-sulfonyl chloride (Maybridge) by the procedure described in Example 152. HR-MS (ES, m/z) calculated for C23H28FN7O4S [(M+H)+] 518.1981, observed 518.1986.
Quellen und Nachweise
- ORD-Eintrag
- ord-3b5d46879eed4e6d8dad3c1caf02ea9c
- Quelldatensatz
- uspto-grants-2007_01