Chlorosuccinimide → 4-Chloro-5-isopropyl-3-trifluoromethylpyrazole

HRID 1372014Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1372014
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[NH:5][N:4]=1.C1C(=O)N([Cl:20])C(=O)C1>CC#N>[Cl:20][C:7]1[C:3]([C:2]([F:1])([F:11])[F:12])=[N:4][NH:5][C:6]=1[CH:8]([CH3:10])[CH3:9]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 230062143-(trifluoroMethyl)-5-isopropyl-1H-pyrazole

Produkt 1

HCID 210711494-Chloro-5-isopropyl-3-trifluoromethylpyrazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

Following protocol L, to the solution of 3-trifluoromethyl-5-isopropyl-pyrazole (0.22 g, 1.23 mmol) in CH3CN (10 mL) was added NCS (0.19 g, 1.43 mmol) in portions with vigorous stirring. The reaction mixture was then heated under reflux for 14 h, cooled and the reaction quenched with saturated NaHCO3, extracted with methylene chloride (2×30 mL) and the combined organic extracts was washed with brine, dried with Na2SO4 and evaporated to give the title compound as a white solid.

Aufarbeitung

  1. temperatureThe reaction mixture was then heated
  2. temperatureunder reflux for 14 h
  3. temperaturecooled
  4. customthe reaction quenched with saturated NaHCO3
  5. extractionextracted with methylene chloride (2×30 mL)
  6. washthe combined organic extracts was washed with brine
  7. dry with materialdried with Na2SO4
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-9366c7670978460d8299927a4adb9d2b
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157464B2

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