Sodium Hydroxide → (4-(6-Chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid

HRID 1372677

Reaktionsgleichung

Reaktionsgleichung von HRID 1372677
[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19]C)=[O:18])=[CH:12][C:11]=3[Cl:21])[S:8][C:4]=2[CH:3]=1.[OH-].[Na+]>C1COCC1>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([NH:9][C:10]3[CH:15]=[CH:14][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:12][C:11]=3[Cl:21])[S:8][C:4]=2[CH:3]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 58778710Methyl (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetate

Produkt 1

HCID 17859264(4-(6-Chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acidAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

Methyl (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetate (271 mg, 0.74 mmol) was dissolved in THF (4.5 ml). To the resulting solution was added 0.5N NaOH (4.5 ml, 2.25 mmol), followed by stirring at room temperature for 15 hours. The reaction mixture was poured in ice-1N HCl. The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give (4-(6-chloro-2-benzothiazolyl)amino-3-chlorophenyl)acetic acid (248 mg, 95%) as a pale yellow solid.

Aufarbeitung

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-58fdca4463604b758be4983dfb04ed57
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157487B2

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