Hydrochloric Acid → 1-(1-Methylethyl)-1H-indole-3-carboxylic acid

HRID 1372692Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1372692
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([O:15]C)=[O:14])=[CH:5]1)([CH3:3])[CH3:2].[OH-].[Na+].Cl>C1COCC1>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([C:13]([OH:15])=[O:14])=[CH:5]1)([CH3:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10443342Methyl 1-(1-methylethyl)-1H-indole-3-carboxylate

Produkt 1

HCID 103979731-(1-Methylethyl)-1H-indole-3-carboxylic acidAusbeute 90,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

In THF (8.0 ml) was dissolved methyl 1-isopropylindole-3-carboxylate (387.6 mg, 1.784 mmol). To the resulting solution was added 0.25N NaOH (8.0 ml). The resulting mixture was stirred at 50° C. for 18 hours. After cooling to room temperature, the reaction mixture was acidified with 1N HCl (4.5 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water and dried under reduced pressure to give 1-isopropylindole-3-carboxylic acid (327.8 mg, 90%) as a pale pink amorphous substance.

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. customThe crystals thus precipitated
  3. filtrationwere collected by filtration under reduced pressure
  4. washwashed with water
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-65d9c0157ad14ecfb548ad0e660868ee
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157487B2

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