Tetrahydrofuran → (3-Chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid

HRID 1372745

Reaktionsgleichung

Reaktionsgleichung von HRID 1372745
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([O:24]C)=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH3:20])[N:12]=1)=[O:10].C1COCC1.[OH-].[Na+]>Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:21][C:22]([OH:24])=[O:23])[CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH3:20])[N:12]=1)=[O:10]

Komponenten

5

Edukt 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 58778393Methyl (3-chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetate

Produkt 1

HCID 17858964(3-Chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acidAusbeute 95,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

To methyl (3-chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetate (1.08 g, 3.02 mmol) were added THF (30 ml) and 0.25N NaOH (18.1 ml, 4.53 mmol) and the resulting mixture was stirred at room temperature for 16 hours. The reaction mixture was poured in 1N HCl (5.0 ml). The crystals thus precipitated were collected by filtration under reduced pressure, washed with water, and dried under reduced pressure to give (3-chloro-4-((1-methyl-3-indazolylcarbonyl)amino)phenyl)acetic acid (0.99 g, 95%) as a brown solid.

Aufarbeitung

  1. customThe crystals thus precipitated
  2. filtrationwere collected by filtration under reduced pressure
  3. washwashed with water
  4. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-cfdf65ddbf564163a331a71c8e55848f
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07157487B2

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