Triphenylphosphine → 2-[4-(1-azabicyclo[2.2.2]oct-3-yloxy)phenyl]-1H-indole

Under N2, the mixture of product from Example 6A (114 mg, 0.5 mmol), the product from Example 6B (157 mg, 0.5 mmol), CuI (Strem Chemicals, 14 mg, 0.075 mmol), PPh3 (Aldrich, 39 mg, 0.15 mmol) and K3PO4 (212 mg, 1 mmol) in dioxane (5 mL) was stirred at 80° C. for 20 h. After the reaction was complete, it was diluted with EtOAc (30 mL) and washed with brine (2×5 mL). The organic solution was concentrated under reduced pressure and the title compound was purified by chromatography (SiO2, CH2Cl2:MeOH:NH3.H2O, 90:10:1, Rf. 0.30) as solid (70 mg, yield, 44%). 1H NMR (300 MHz, CD3OD) δ 1.45–1.59 (m, 1H), 1.65–1.91 (m, 2H), 2.00–2.14 (m, 1H), 2.17–2.24 (m, 1H), 2.75–3.01 (m, 5H), 3.31–3.42 (m, 1H), 4.54–4.62 (m, 1H), 6.66 (d, J=0.7 Hz, 1H), 6.93–7.00 (m, 3H), 7.01–7.08 (m, 1H), 7.35 (dq, J=8.2, 1.0 Hz, 1H), 7.48 (dq, J=7.8, 0.7 Hz, 1H), 7.71 (dt, J=8.8, 2.6 Hz, 2H) ppm. MS (DCl/NH3): m/z 319 (M+H)+.

1. washwashed with brine (2×5 mL)
2. concentrationThe organic solution was concentrated under reduced pressure
3. customthe title compound was purified by chromatography (SiO2, CH2Cl2:MeOH:NH3.H2O, 90:10:1, Rf. 0.30) as solid (70 mg, yield, 44%)

ORD-Eintrag

ord-27942f942ac84a1a81a07194d9cb60d2

Quelldatensatz

uspto-grants-2007_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07160876B2