Sodium Hydroxide → 3-(1-Ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone

HRID 1373138Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1373138
[OH-].[Na+].C([N:6]1[C:14]2[C:9](=[CH:10][C:11]([N:15](C(=O)C)[S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:18])=[O:17])=[CH:12][CH:13]=2)[C:8](=[C:28]([O:35][CH2:36][CH3:37])[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[C:7]1=[O:38])(=O)C>ClCCl.C(O)C>[CH2:36]([O:35][C:28](=[C:8]1[C:9]2[C:14](=[CH:13][CH:12]=[C:11]([NH:15][S:16]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)(=[O:17])=[O:18])[CH:10]=2)[NH:6][C:7]1=[O:38])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[CH3:37]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 695098291-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-(N-acetyl-N-phenylsulphonyl-amino)-2-indolinone

Produkt 1

HCID 695105493-(1-Ethoxy-1-phenyl-methylidene)-5-phenylsulphonylamino-2-indolinone

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

8 ml of 4 N sodium hydroxide solution are added to a solution of 4.0 g (8 mmol) of 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-5-(N-acetyl-N-phenylsulphonyl-amino)-2-indolinone (Example 1e) in a mixture of 20 ml of dichloromethane and 20 ml of ethanol and the resulting mixture is stirred for 20 minutes at ambient temperature. It is then evaporated down to about. 10 ml and 150 ml of water are added. The pH is adjusted to 8–9 with 1 N hydrochloric acid. The precipitate formed is suction filtered, washed with water, isopropanol and ether, then dried in vacuo.

Aufarbeitung

  1. customIt is then evaporated down to about
  2. addition10 ml and 150 ml of water are added
  3. customThe precipitate formed
  4. filtrationfiltered
  5. washwashed with water, isopropanol and ether
  6. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-ba86cf0e17ae4f448c9a4d64932f3d8f
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07160901B2

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