Sodium hydroxide tetrahydrofuran → HCID 58780929, Verbindung

HRID 1373191

Reaktionsgleichung

Reaktionsgleichung von HRID 1373191
[OH-].[Na+].C1COCC1.[CH:8]([O:11][C:12]1[CH:13]=[C:14]([CH:28]=[C:29]([CH2:31][N:32]([S:34]([C:37]2[CH:42]=[CH:41][C:40]([CH3:43])=[CH:39][CH:38]=2)(=[O:36])=[O:35])[CH3:33])[CH:30]=1)[C:15]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]([O:26]C)=[O:25])=[CH:20][N:19]=1)=[O:16])([CH3:10])[CH3:9]>>[CH:8]([O:11][C:12]1[CH:13]=[C:14]([CH:28]=[C:29]([CH2:31][N:32]([S:34]([C:37]2[CH:42]=[CH:41][C:40]([CH3:43])=[CH:39][CH:38]=2)(=[O:35])=[O:36])[CH3:33])[CH:30]=1)[C:15]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]([OH:26])=[O:25])=[CH:20][N:19]=1)=[O:16])([CH3:10])[CH3:9]

Komponenten

3

Edukt 2

HCID 20445995Sodium hydroxide tetrahydrofuranHCID 58780889HCID 58780889, Verbindung

Produkt 1

HCID 58780929HCID 58780929, Verbindung

Versuchsvorschrift

Standard ester hydrolysis (2M NaOH/THF), as described in Example A, of methyl 2-{3-isopropyloxy-5-[(N-methyl) 4-toluenesulfonylaminomethyl]benzoyl}amino-5-pyridine carboxylate gave the title compound as a pale yellow solid, 1H NMR δ (d6-DMSO): 1.23 (d, 6H), 2.40 (s, 3H), 2.58 (s, 3H), 4.13 (s, 2H), 4.62–4.72 (m, 1H), 7.70 (s, 1H), 7.41–7.52 (m, 4H), 7.73 (d, 2H), 8.31 (s, 2H), 8.84 (s, 1H), 11.16 (s, 1H) m/z 498 (MH)+, 496 (M−H)−.

Quellen und Nachweise

ORD-Eintrag
ord-7768c6410252413a8e01fbbe6b351989
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07160906B2

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