1-(1-Naphthyl)piperazine hydrochloride → 7-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butoxy]-5-trifluoromethyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

HRID 1373615

Reaktionsgleichung

Reaktionsgleichung von HRID 1373615
Cl.[C:2]1([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1.[O:18]=[C:19]1[NH:28][C:27]2[N:26]=[C:25]([O:29][CH2:30][CH2:31][CH2:32][CH:33]=O)[CH:24]=[C:23]([C:35]([F:38])([F:37])[F:36])[C:22]=2[CH2:21][CH2:20]1>>[C:2]1([N:12]2[CH2:17][CH2:16][N:15]([CH2:33][CH2:32][CH2:31][CH2:30][O:29][C:25]3[N:26]=[C:27]4[C:22]([CH2:21][CH2:20][C:19](=[O:18])[NH:28]4)=[C:23]([C:35]([F:37])([F:36])[F:38])[CH:24]=3)[CH2:14][CH2:13]2)[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 27373911-(1-Naphthyl)piperazine hydrochlorideHCID 210733764-(7-Oxo4-trifluoromethyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde

Produkt 1

HCID 210738137-[4-(4-Naphthalen-1-yl-piperazin-1-yl)-butoxy]-5-trifluoromethyl-3,4-dihydro-1H-[1,8]naphthyridin-2-one

Versuchsvorschrift

In a manner similar to that of other examples above, 1-naphthalen-1-yl-piperazine hydrochloride was coupled by reductive amination to 4-(7-oxo-4-trifluoromethyl-5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yloxy)-butyraldehyde followed by typical workup and purification to give the title compound. MS: APCI: M+1: 499.1 (Exact Mass: 489.22).

Aufarbeitung

  1. customfollowed by typical workup and purification

Quellen und Nachweise

ORD-Eintrag
ord-b8c9c417c92f47c78a1a2096b13e86d6
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07160888B2

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