HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetic Acid → 5-Chloro-2-[1-(1-methyl-hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetic Acid | HCID 176 | — |
| Edukt | 1-Methylazepan-4-one | HCID 262586 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | 5-chloro-2-(piperidin-4-ylcarbonylamino)-N-(5-chloropyridin-2-yl)-benzamide | HCID 21075334 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 5-Chloro-2-[1-(1-methyl-hexahydroazepin-4-yl)piperidin-4-ylcarbonylamino]-N-(5-chloropyridin-2-yl)benzamide | HCID 21075317 | — |
Reaktionsschritte
The title compound is prepared from 5-chloro-2-(piperidin-4-ylcarbonylamino)-N-(5-chloropyridin-2-yl)-benzamide and 1-methyl-hexahydro-4H-azepin-4-one by reductive alkylation using NaCNBH3 and 5%-acetic acid in methanol, for example using a procedure similar to that of Example 25-F.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07163938B2 |
| Quelldatensatz | uspto-grants-2007_01 |
| ORD ID | ord-f3ea6a1a0d5a4e8ab9034749e7fa23fe |
| Quellennotiz | uspto-grants-2007_01 |