Ethyl 2-(4-cyanophenyl)acetate → Ethyl 2-(4-(aminomethyl)phenyl)acetate

HRID 1374733Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1374733
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][CH:4]=1)#[N:2]>N.[Ni]>[NH2:2][CH2:1][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:5][CH:4]=1

Komponenten

4

Edukt 1

HCID 279718Ethyl 2-(4-cyanophenyl)acetate

Produkt 1

HCID 11535728Ethyl 2-(4-(aminomethyl)phenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 935NickelKatalysatorHCID 222AmmoniaLösungsmittel

Versuchsvorschrift

0.5 g (2.6 mmol) of ethyl (4-cyanophenyl)acetate was dissolved in 70 ml of ethanolic ammonia solution and hydrogenated, at room temperature and under standard pressure, over Raney nickel. After 45 minutes, the mixture was filtered and evaporated. This resulted in 0.42 g (82%) of ethyl (4-aminomethylphenyl)acetate. MS (ES+): m/e=194.11

Aufarbeitung

  1. filtrationthe mixture was filtered
  2. customevaporated
  3. customThis resulted in 0.42 g (82%) of ethyl (4-aminomethylphenyl)acetate

Quellen und Nachweise

ORD-Eintrag
ord-c29348e54dc74efa97f6cfaf37f94093
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166609B2

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