4-(Aminomethyl)piperidine → tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)

HRID 1374828Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1374828
NCC1CCNCC1.[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1.C(OCC)(=O)C.[ClH:30]>C(OCC)(=O)C>[ClH:30].[NH2:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1

Komponenten

5

Edukt 3

HCID 235274-(Aminomethyl)piperidineHCID 7368171-Boc-4-(aminomethyl)piperidineHCID 21866389Hydrogen chloride-ethyl acetate

Produkt 1

HCID 2756034tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate--hydrogen chloride (1/1)Ausbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

By using 4-aminomethylpiperidine 5.71 g as a starting material, tert-butyl 4-aminomethylpiperidine-1-carboxylate was prepared according to the method described in Synthetic Commun., 22(16), 2357–2360 (1992). The resulting compound was dissolved in 80 ml of ethyl acetate, and the solution was added with 4N hydrogen chloride-ethyl acetate and stirred. The precipitated solids were collected by filtration to obtain the title compound (10.27 g, yield: 82%).

Aufarbeitung

  1. customwas prepared
  2. filtrationThe precipitated solids were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-2ddb96259e7d41479389f7fbc4da843d
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166617B2

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