Chloroacetyl chloride → 2-chloro-N,N-diphenyl-Acetamide

HRID 1374837

Reaktionsgleichung

Reaktionsgleichung von HRID 1374837
[Cl:1][CH2:2][C:3](Cl)=[O:4].[C:6]1([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1(C)C=CC=CC=1.O1CCCC1>[Cl:1][CH2:2][C:3]([N:12]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

Komponenten

5

Edukt 2

HCID 6577Chloroacetyl chlorideHCID 11487Diphenylamine

Produkt 1

HCID 2244812-chloro-N,N-diphenyl-AcetamideAusbeute 75,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

Chloroacetyl chloride (0.32 ml, 4.02 mmol) was dissolved in a mixed solvent of toluene (6 ml) and tetrahydrofuran (2 ml). The solution was added with diphenylamine (690 mg, 4.08 mmol) at room temperature, and the heated at 100° C. for 80 minutes. The solvent was evaporated under reduced pressure, and the solid precipitated was suspended and washed in ethyl ether. The solid was collected by filtration and dried under reduced pressure to obtain the title compound as colorless solid (746 mg, yield: 75%).

Aufarbeitung

  1. customThe solvent was evaporated under reduced pressure
  2. customthe solid precipitated
  3. washwashed in ethyl ether
  4. filtrationThe solid was collected by filtration
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f223e951be944d738507469f0bceee6f
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166617B2

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