Ethylene Glycol → HCID 22394927, Verbindung

HRID 1375122Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1375122
[CH3:1][CH:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH:3]1[S:9]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:11])=[O:10].[CH2:18](O)[CH2:19][OH:20].C(=O)(O)[O-].[Na+]>C1C=CC=CC=1>[CH2:18]1[CH2:19][O:20][C:5]2([CH2:6][CH2:7][CH:2]([CH3:1])[CH:3]([S:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)(=[O:10])=[O:11])[CH2:4]2)[O:8]1

Komponenten

5

Edukt 3

HCID 174Ethylene GlycolHCID 516892Sodium BicarbonateHCID 223949304-Methyl-3-(phenylsulfonyl)-cyclohexan-1-one

Produkt 1

HCID 22394927HCID 22394927, VerbindungAusbeute 97 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

To a solution of 2.45 g of 4-methyl-3-(phenylsulfonyl)-cyclohexan-1-one in 40 ml of benzene, were added 0.7 ml of 1,2-ethanediol and 0.2 g of anhydrous paratoluenesulfonic acid. The resulting mixture was heated under reflux for 4 hours. After the reaction, a 2M aqueous sodium bicarbonate solution was added and the resulting mixture was extracted with ethyl acetate three times. The combined organic layers were washed with saturated saline, and dried over magnesium sulfate. The solvent was then distilled off under reduced pressure. The residue was recrystallized from ethyl ether, whereby 1,1-(ethylenedioxy)-4-methyl-3-(phenylsulfonyl)-cyclohexane was obtained in the form of white crystals. Yield: 97%, Melting point: 105 to 106° C.

Aufarbeitung

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for 4 hours
  3. customAfter the reaction
  4. extractionthe resulting mixture was extracted with ethyl acetate three times
  5. washThe combined organic layers were washed with saturated saline
  6. dry with materialdried over magnesium sulfate
  7. distillationThe solvent was then distilled off under reduced pressure
  8. customThe residue was recrystallized from ethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-cc9633e2e1ac41dc8a7fa14151867efc
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166642B1

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