L-Tryptophan → 4-Bromo-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]benzenesulfonamide

HRID 1375191

Reaktionsgleichung

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH2:12]1[CH2:17][CH2:16][CH:15]([C@H:18]([NH2:22])[C:19](O)=[O:20])[CH2:14][CH2:13]1.C1C([C@@H](N)C(O)=O)=CC=C(O)C=1.N[C@@H](C(O)=O)CCSC.N[C@H](C(O)=O)CC1C2C(=CC=CC=2)NC=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:22][C@@H:18]([CH:15]2[CH2:16][CH2:17][CH2:12][CH2:13][CH2:14]2)[CH2:19][OH:20])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Komponenten

Edukt 5

HCID 6305L-Tryptophan

HCID 7396p-Bromobenzenesulfonyl chloride

HCID 84815D-Methionine

HCID 89853D-p-hydroxyphenylglycine

HCID 736848(alphaS)-alpha-Aminocyclohexaneacetic acid

Produkt 1

HCID 99758744-Bromo-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]benzenesulfonamide

Versuchsvorschrift

The following compounds (Examples 16–19, Table 3) were prepared using 4-bromobenzensulfonyl chloride with L-cyclohexylglycine, D-4-hydroxyphenylglycine, D-methionine, and L-tryptophan and following the procedure outlined in Example 16.

Aufarbeitung

customThe following compounds (Examples 16–19, Table 3) were prepared

Quellen und Nachweise

ORD-Eintrag: ord-0507b1a70948434eb1199e38438ef8e8
Quelldatensatz: uspto-grants-2007_01
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US07166622B2

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