p-Bromobenzenesulfonyl chloride → 4-Bromo-N-[(1R,2R)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide

HRID 1375192

Reaktionsgleichung

Reaktionsgleichung von HRID 1375192
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.ClC1C=CC(S(Cl)(=O)=O)=CC=1.[NH2:23][C@@H:24]([C:29](O)=[O:30])[C@@H:25]([CH2:27][CH3:28])[CH3:26].CC([C@](N)(C(O)=O)C)C.CC(C1C=CC=CC=1)C(C(O)=O)N.N[C@H](C(O)=O)[C@@H](CC)C>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:23][C@@H:24]([CH2:29][OH:30])[C@H:25]([CH3:26])[CH2:27][CH3:28])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Komponenten

7

Edukt 6

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 73984-Chlorobenzenesulfonyl chlorideHCID 648082-Amino-3-phenylbutanoic acidHCID 76551D-IsoleucineHCID 99288Alloisoleucine, DL-HCID 7408715(S)-2-amino-2,3-dimethylbutanoic acid

Produkt 1

HCID 103370674-Bromo-N-[(1R,2R)-1-(hydroxymethyl)-2-methylbutyl]benzenesulfonamide

Versuchsvorschrift

The following compounds (Examples 33–39, Table 5) were prepared using 4-bromobenzenesulfonyl chloride, and 4-chlorobenzenesulfonyl chloride, with D-isoleucine, L-α-methyl-valine, β-methyl-DL-phenylalanine, and L-allo-isoleucine and following the procedure outlined in Example 33. This procedure is outlined in the following Scheme.

Aufarbeitung

  1. customThe following compounds (Examples 33–39, Table 5) were prepared

Quellen und Nachweise

ORD-Eintrag
ord-584039e801454c479c6577ce1f234983
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166622B2

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