Tin tetrachloride → Ethyl 4-[1-(6-methyl-pyrid-3-yl)-3,4-dihydro-4,4-dimethyl-anthracen-8-yl]-benzoate

HRID 1375268

Reaktionsgleichung

Reaktionsgleichung von HRID 1375268
[CH3:1][C:2]1S[C:5]([C:7]2[C:20]3[C:11](=[CH:12][C:13]4[C:18]([CH:19]=3)=[C:17]([C:21]3[CH:31]=[CH:30][C:24]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:23][CH:22]=3)[CH:16]=[CH:15][CH:14]=4)[C:10]([CH3:33])([CH3:32])[CH2:9][CH:8]=2)=[CH:4][CH:3]=1.C[C:35]1C=CC(C2(C=O)C3C(=CC=CC=3)C(C)(C)CC2)=C[N:36]=1.C(OP(C(OC)(OC)CCC1C=CC(C(OCC)=O)=CC=1)(OCC)=O)C.COC(OC)C/C(/C1C=CC(C(OCC)=O)=CC=1)=C\C1C=C2C(C(C)(C)CC=C2C2C=CC(C)=CC=2)=CC=1.Cl[Sn](Cl)(Cl)Cl>ClCCl>[CH3:1][C:2]1[N:36]=[CH:35][C:5]([C:7]2[C:20]3[C:11](=[CH:12][C:13]4[C:18]([CH:19]=3)=[C:17]([C:21]3[CH:31]=[CH:30][C:24]([C:25]([O:27][CH2:28][CH3:29])=[O:26])=[CH:23][CH:22]=3)[CH:16]=[CH:15][CH:14]=4)[C:10]([CH3:33])([CH3:32])[CH2:9][CH:8]=2)=[CH:4][CH:3]=1

Komponenten

7

Edukt 5

HCID 24287Tin tetrachlorideHCID 18620054Ethyl 4-[1-(5-methyl-thien-2-yl)-3,4-dihydro 4,4-dimethyl-anthracen-8-yl]-benzoate2×HCID 57037360Ethyl 4-(diethoxyphosphoryl-3,3-dimethoxypropyl)benzoate2×HCID 865886781(2-Methyl-pyrid-5-yl)3,4-dihydro-4,4-dimethyl-naphthaldehyde2×HCID 86588679Ethyl 4-[1-(2,2-dimethoxyethyl)-2-{1(tol-4-yl)3,4-dihydro-4,4-dimethyl-naphthalen-7-yl}-(E)-ethenyl]-benzoate

Produkt 1

HCID 18620059Ethyl 4-[1-(6-methyl-pyrid-3-yl)-3,4-dihydro-4,4-dimethyl-anthracen-8-yl]-benzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

This compound is prepared in accordance with the procedure described for the preparation of ethyl 4-[1(5-methyl-thien-2-yl)3,4-dihydro-4,4-dimethyl-anthracen-8-yl]-benzoate (Compound 3), from 1(2-methyl-pyrid-5-yl)3,4-dihydro-4,4-dimethyl-naphthaldehyde (Compound K) by reaction with ethyl 4-(diethoxyphosphoryl-3,3-dimethoxypropyl)benzoate (Compound D) and proceeding through the intermediate ethyl 4-[1-(2,2-dimethoxyethyl)-2-{1-(tol-4-yl)3,4-dihydro-4,4-dimethyl-naphthalen-7-yl}-(E)-ethen-1-yl]-benzoate which is cyclized by treatment with SnCl4 in dichloromethane to give the title compoud.

Aufarbeitung

  1. customThis compound is prepared in accordance with the procedure
  2. customto give the title compoud

Quellen und Nachweise

ORD-Eintrag
ord-bc4b7bd7985d4541a8c639f8cc3c3758
Quelldatensatz
uspto-grants-2007_01
Patentnummer
US07166726B2

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