Thionyl Chloride → HCID 86625063, Verbindung

HRID 13756Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 13756
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:20])[C:10]=1[CH2:11][N:12]1[CH2:16][CH2:15][C@H:14]([N:17]([CH3:19])[CH3:18])[CH2:13]1)[C:5](O)=[O:6].S(Cl)([Cl:23])=O>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:20])[C:10]=1[CH2:11][N:12]1[CH2:16][CH2:15][C@H:14]([N:17]([CH3:19])[CH3:18])[CH2:13]1)[C:5]([Cl:23])=[O:6]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 686902813,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid

Produkt 1

HCID 86625063HCID 86625063, Verbindung

Versuchsvorschrift

This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 3,5-dichloro-4-[(S)-3-(dimethylamino)pyrrolidin-1-ylmethyl]benzoic acid obtained in the step 4 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated twice.

Aufarbeitung

  1. customobtained in the step 4
  2. distillationwas distilled off under reduced pressure
  3. additionthe operation of adding of toluene to the residue
  4. customfollowed by azeotropic removal of thionyl chloride

Quellen und Nachweise

ORD-Eintrag
ord-51a8e10028bf4ad2bbe3361dd4f7becc
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728131B2

Notizen zur Reaktion

Wird geladen…